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DIVISION OF
CARDIOLOGY
Division Highlights
The Division of Pediatric Cardiology's clinical programs in diagnostic and interventional cardiology
continue to grow, serving an ever larger and more complex pediatric population with a wide variety of
congenital and acquired heart conditions. Board certified pediatric cardiologists, clinical nurse
specialists and social workers are tireless in research and clinical application of innovative modalities for
comprehensive cardiac evaluation. Offering a wide range of treatment options, this team of outstanding
medical professionals provides precise medical management, preoperative diagnosis and conscientious
postoperative care resulting in clinical outcomes which are among the best in the world.
In 1999, the division engaged in
a unique strategic planning initiative to optimize the research and clinical
expertise of the faculty for the benefit of the children we treat. In several
intensive sessions guided by an experienced independent consultant, every
Pediatric Cardiology medical program was examined and reengineered toward
providing better care and more usable scientific information in an increasingly
challenging business environment. Pediatric Cardiology Research and Clinical
Faculty then engaged the Division of Cardiothoracic Surgery in this dynamic
process, which, on a continuing basis, is expected to significantly enhance
outcomes.
During the year, Pediatric
Cardiology expanded use of advanced diagnostic modalities to give children with
cardiac diagnoses the finest in treatment. The neonatal echocardiography
program, using state-of-technology cardiac image capture and transmission,
provides real time cardiodiagnostic consultations to physicians at community
hospitals. The use of high resolution imaging technology providing clear
anatomic data has resulted in growth of the fetal echocardiography program, and
the delivery of increasing numbers of high risk infants at UCLA.
The volume of cases in the
pediatric cardiac catheterization and electrophysiology programs continues an
upward trend in providing the latest catheter-directed therapies to correct
anatomic cardiac defects and to cure abnormal heart rhythms. As pediatric
patients from the Western U.S. and Pacific Rim, as well as other countries, come
to benefit from these outstanding programs, Mattel Children's Hospital at UCLA
grows in recognition as a national leader in pediatric cardiac intervention.
The pediatric cardiac
transplantation program continued to increase the number of children evaluated
and listed for heart transplantation. As children from the world over came to
UCLA to receive new hearts, the attention of the media was drawn to the high
skill and accomplishments of the pediatric cardiologists and cardiothoracic
surgeons at Mattel Children's Hospital. Along with the transplant program,
giving hope to children whose hearts are failing, UCLA's Pediatric
Cardiomyopathy Program is improving the cardiac health of children for whom, in
years past, the only option would be transplant.
The Community Pediatric
Cardiology Network, instituted by the Division in 1997, has expanded the
opportunity for children in the larger community to benefit from the experience
and cardiovascular research discoveries of the pediatric cardiology faculty of
Mattel Children's Hospital at UCLA. UCLA pediatric cardiologists provide
services to Olive View-UCLA Medical Center, Venice Family Clinic, Los Angeles
Orthopaedic Hospital and San Bernardino County Hospital. The full-time pediatric
cardiology outreach practice in Thousand Oaks, approximately 45 miles northwest
of Mattel Children's Hospital at UCLA is thriving. Many pediatric cardiologists
in private practice throughout the Southland and in neighboring states
increasingly consult with our faculty, referring their patients to UCLA for the
superior diagnostic skill and advanced treatment options the community has come
to expect from Mattel Children's Hospital at UCLA.
Faculty
Profiles
ALEJOS, JUAN CARLOS
| Faculty Member Since: |
1993
|
| Degrees: |
MD, BS, University of
Michigan
|
| Rank: |
Assistant Clinical
Professor
|
| Research Interests: |
Outcomes research on
children with single ventricle physiology, dilated cardiomyopathy and heart
transplantation
|
| Teaching: |
Housestaff while on
clinical rotations, clinics
|
| University Service: |
Critical Care Committee
Respiratory Therapy Quality Assurance Committee
UCLA/PAMS Cardiovascular Exchange Program providing medical and surgical interventions for children
with congenital heart disease in Peru
|
| Professional Committees: |
Committee for Congenital Heart Disease in the Young
|
ALLADA, VIVEK
| Faculty Member Since: |
1992 |
| Degrees: |
MD, BS, University of
Michigan |
| Rank: |
Assistant Professor In
Residence |
| Research Interests: |
Coronary artery
abnormalities of childhood, application of Cardiac Positron Emission
Tomography (PET) in children, Cardiac effects of human growth hormone therapy,
Transesophageal echocardiography
|
| Grant Support: |
1997-02
Pharmacia & Upjohn Co., Multicenter, double blind clinical trial of
Genotropin, Cardiology consultant |
| Teaching: |
Director, UCLA Pediatric Cardiology Fellowship Training Program
Didactic lectures of Pediatric residents and fellows
Participant, 1999 Pediatric/Congenital Heart Gross Laboratory Pathology Course for UCLA Medical Students
Director, UCLA Cardiothoracic Surgical Pre-operative conference
Attending Physician, Cardiology Fellow's Continuity Clinic
|
| University Service: |
Member,
UCLA Radiation Safety Committee, 1996-present
|
| Professional
Committee:
|
Member,
Dept. of Pediatrics Group Practice Plan Executive Committee
Member, Dept. of Pediatrics Grand Rounds Committee, 1999-present
Member, American College of Cardiology Pediatric Cardiology Training
Program Directors' Subcommittee, 1998-present
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CHEN, FUHUA
| Faculty Member Since: |
1992
|
| Degrees: |
MD, MS, Suzhou Medical
College |
| Rank: |
Adjunct Assistant Professor /
Assistant Researcher |
| Research Interests: |
Structure and function of
ion transport protein in excitation-contraction coupling in developing heart,
Signal pathway in regulation of ionic current in myocardium
|
| Grant Support: |
American
Heart Association, Grant-in-Aid award
UCLA Laubisch Fund for cardiovascular Research Award
Pediatric AIDS Foundation Scientists Award
|
| Teaching: |
Didactic conference lecturing for fellows and residents
Lab Supervisor for graduate and undergraduate students
Laboratory bi-weekly New Experimental method mini-review
Co-mentor, American Heart Association Summer Training Program
|
| University Service: |
Mentor
and Supervisor: Harvey Mudd College Math & Science Internship Program at
UCLA
Editorial services: Reviewer, Cardiovascular Research
|
| Professional
Committee:
|
Member,American Heart Association
Member, American Physiological Society
Member, American Association for the Advancement of Science
Member, The Western Society for Pediatric Research
|
DRANT, STACY
| Faculty Member Since: |
1994
|
| Degrees: |
MD, Brown University
BS, University of California, Los Angeles
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| Rank: |
Assistant Professor
|
| Research Interests: |
Clinical management of patients with Pulmonary Atresia with Intact
Interventricular Septum, right ventricular growth in Pulmonary atresia
with intact interventricular septum, coronary abnormalities in patients
with pulmonary atresia with intact interventricular septum. Development
and diagnosis of congenital heart disease in utero
|
| Teaching: |
Medical students- cardiac pathophysiology course
Residents-ward service/outpatient clinic
Fellows-organize echocardiography weekly didactic conference, inpatient
service and outpatient clinic
|
| University Service: |
Director of the pediatric echocardiography lab
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| Professional
Committee:
|
Hospital planning committee
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FRIEDMAN, WILLIAM
| Faculty Member Since: |
1979
|
| Degrees: |
MD, State University of NY, Downstate
BA, Columbia College
|
| Rank: |
Professor
|
| Research Interests: |
Developmental Cardiovascular Physiology
|
| Teaching: |
Pediatric Clerkship
Pathophysiology of Disease
UCLA Sophomore Class Advanced Clinical Clerkship
Pediatric Cardiology
|
| University Service: |
Senior Associate Dean for Academic Affairs
J.H. Nicholson Professor of Pediatrics (Cardiology)
Member, Advisory Board, Program Project - PACS
(Picture Archiving and Communication System)
Chairman, Dean's Laubisch Endowment Advisory Committee
Member, Liaison Committee on Medical Education (LCME)
Committee on Governance Administration
Member, Provost Advisory Team
Chairman, Medical Advisory Board, SPRINT Program0
(Special Preventive Research, Intervention and New Technology)
Consulting Member, Jules Stein Eye Institute
|
| Professional Committees: |
Member, Air Resources Board, California Environmental
Protection Agency, State of California
President, Intersociety Council for Pediatric Cardiology
Member, Advisory Board, CHILD (Clearinghouse for Information on Learning Disabilities)
|
GALINDO, ALVARO
| Faculty Member Since: |
1990 |
| Degrees: |
MD, BS, University of
Miami |
| Rank: |
Assistant Clinical
Professor |
GEORGE, BARBARA
| Faculty Member Since: |
1980 |
| Degrees: |
MD, University of California, Los Angeles
BA, University of California, Berkeley |
| Rank: |
Associate Professor of
Clinical Pediatrics
|
| Research Interests: |
Cardiomyopathy, transplantation, cardiovascular surgical outcomes,surgical data base.
|
| Teaching: |
Department of Pediatrics, UCLA Center for the Health Sciences - Noon Lecture Series;Pediatric Cardiology
Medical Student Outpatient Specialty Elective Rotation, Pediatric Cardiology, Course # 251.02-Director
Pediatric Cardiology Sub-specialty rotation (PL II, III, MS IV) - Director |
| University Service: |
Quality Assurance (QA) Committee, Department of Pediatrics _ Member
Risk Management Committee, Medical Staff (Hospital) - Member Quality Assurance (QA) Committee, Medical Staff (Hospital), now
Performance Improvement Committee _ Member Acute Care College Planning Team _ Member |
| Professional Committees: |
American College of Cardiology- Fellow
American Academy of Pediatrics, Section on Cardiology- Member
Pediatric Heart and Lung Transplant Study Group _ Member
American College of Cardiology, California Chapter:
Pediatric Cardiology Committee _ Member
Western Society for Pediatric Research _ Member
International Society for Heart and Lung Transplantation _ Member
|
KAPLAN, SAMUEL
| Faculty Member Since: |
1987
|
| Degrees: |
MD, MB, BCh, University of Witwatersrand (South Africa)
|
| Rank: |
Professor Emeritus
|
| Research Interests: |
Cardiovascular Complications of Vertically Transmitted HIV Infection
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| Grant Support: |
1989-00 National Heart, Lung and Blood Institute, National Institutes of Health
|
| Professional Committees: |
National Heart, Lung and Blood Institute study on cardiopulmonary complications of HIV infection:
Chairman, Cardiology Sub-committee, Chairman of Publication Committees, Member of the Steering Committee and Member of Policy, Data and Safety Monitoring Board
Member, Scientific Advisory Committee on Pediatric Cardiomyopathy Supported By National Heart, Lung and Blood Institute
|
| University Service: |
Member Human Subjects Protection Committee
|
| Honors:
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Kaplan Visionary Award, presented by the American
Heart Association, Cincinnati, Ohio, February 27, 1999
Chair, Plenary session American College of Cardiology in
Adult Congenital Heart Disease, New Orleans, March 8, 1999
Founders Award, Section of Pediatric Cardiology American Academy of
Pediatrics, Washington DC., October 10, 1999 |
KLITZNER, THOMAS
| Faculty Member Since: |
1984
|
| Degrees: |
PhD, Physiology - University of Pennsylvania
MD, Medicine - University of Pennsylvania School of Medicine
MS, Mechanical Engineering - Massachusettes Institute of Technology
AB, Physics - Harvard University
|
| Rank: |
Professor
|
| Grant Support: |
Pediatric Aids Foundation, Basic Research
|
| Committee Service:
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Department of Pediatrics Practice Plan Review Committee
Department of Pediatrics Compliance Committee
Department of Pediatrics Credentialing Committee
Department of Pediatrics Executive Committee
|
| Community Service: |
Advisor, Harvard University Health Alumnae Advisory Service
Board Member, Camp Del Corazon Foundation
Board Member, American Heart Association, West Los Angeles Division
Board Member, Heart of a Child Foundation
|
LEONG, FREDERIC
| Faculty Member Since: |
1996
|
| Degrees: |
MD, University of Missouri
|
| Rank: |
Assistant Clinical Professor
|
MOSS, ARTHUR
| Faculty Member Since: |
1952
|
| Degrees: |
BS, MD, MB, MS in Pediatrics
|
| Rank: |
Professor Emeritus
|
| Teaching: |
Cardiology and General Pediatrics (no structured teaching)
|
PERLOFF, JOSEPH
| Faculty Member Since: |
1978
|
| Degrees: |
MD, Louisiana State University
BA, Tulane University
MA, (Honorary) University of Pennsylvania
|
| Rank: |
Professor
|
| Research Interests: |
Congenital Heart Disease in Adults
|
SHANNON, KEVIN
| Faculty Member Since: |
1995
|
| Degrees: |
MD, Columbia University
BS, Haverford College
|
| Rank: |
Assistant Professor In Residence
|
| Research Interests: |
Mechanisms of Cardiomuopathy in HIV Disease
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WETZEL, GLENN
| Faculty Member Since: |
1991
|
| Degrees: |
PhD, MD, University of California - San Diego
BS, University of California - Los Angeles
|
| Rank: |
Associate Professor
|
| Research Interests: |
Calcium channel kinetics in acutely isolated fetal, neonatal, and adult
rabbit cardiac myocytes; studies of the mechanisms regulating the maturation of excitation-contraction coupling in developing heart, and
factors which influence the effectiveness of radiofrequency ablation of cardiac arrhythmias in pediatric patients.
|
| University Service: |
Pediatric Endocrinologist Search Committee
Department of Anesthesia Search Committee
Chairman, Molecular Cardiologist Search Committee
Member, Department of Pediatrics Group Practice Executive Board
|
| Professional Committees: |
Research Committee, American Heart Association, Western States Affiliate
Committee on Congenital Cardiac Defects, American Heart Association, National Center
|
Division
Publications
-
Chang RK, Alejos JC, Atkinson D, Jensen R,
Drant S, Galindo A, Laks H. Bubble
Contrast Echocardiography in Detecting Pulmonary Arteriovenous Malformation in Children with
Univentricular Heart after Cavopulmonary Anastomosis 1999.
- Chang RK, Klitzner TS. Repairing Tetralogy of Fallot—Does Age Matter? Letter to the Editor,
JACC Vol.34, No. 5 1999.
- Chang RKR, Chen AY, Klitzner
TS. Factors associated with age at operation for children with
congenital heart disease. Pediatrics (In Press) 1999.
- Chen F, and Klitzner TS. Cardiac
K+ Channel Expression and Function at Birth and in the Neonate.
Potassium Channels in Cardiovascular Biology. S.L. Archer and N.J. Rusch, Eds. (In Press) 1999.
- Chen F, Naim S, Friedman WF, Klitzner
TS and Wetzel GT. Agedependent changes in the effects
of amiodarone on rabbit cardiac myocyte contractions. J Cardiovasc Pharmacol Therapeut 4(1):23-32, 1999.
- Friedman WF. Congenital heart disease in infancy and childhood. In:
Heart Disease (6th ed.), Braunwald
E (ed.). Philadelphia: W.B. Saunders Company, (In press) 1999.
- Laks H, Odim JN, Sadeghi AM, Allada V. The incisional pulmonary artery band. Ann Thorac
Surg 67(6):1813-4, 1999.
- Marelli D, Laks H, Meehan D, Fazio D, Alejos
J. "Minimally Invasive Mechanical Cardiac Support
Without ECMO in Children Awaiting Heart Transplantation" The Annals of Thoracic Surgery, 68:2320-3, 1999.
- Niwa K, Perloff JK, Kaplan S, Child JS, Miner PD. Eisenmenger syndrome in adults: Ventricular
septal defect, truncus arteriosus, univentricular heart. J Am Coll Cardiol 4:223-32, 1999.
- Odim J, Laks H, Drinkwater D, George B, Yun J, Salem M,
Allada,V. Staged surgical approach to neonates with aortic obstruction and single ventricle physiology. Presented at the 35th Annual Meeting of
the Society of Thoracic Surgery, January 25-27, 1999 (Abstract)
- Odim J, Laks H, Sadeghi A, Drinkwater D, Alejos
J, Galindo A, George B, Komanapalli. Pediatric
heart transplantation experience at a single center: a fifteen-year experience. Presented at the
72nd Scientific Sessions of the American Heart Association, November 8, 1999 (Abstract)
- Odim JN, Laks H, Drinkwater DC Jr,
George Bl, Yun J, Salem M, Allada V. Staged surgical approach
to neonates with aortic obstruction and single-ventricle physiology. Ann Thorac Surg 68(3):962-7, 1999.
- Chang R-K R, Alejos JC, Atkinson D, Jensen R,
Drant S, Galindo A, Laks H. Bubble
Contrast Echocardiography in Detecting Pulmonary Arteriovenous Shunting in Children With Univentricular
Heart After Cavopulmonary Anastamosis. Pediatric Cardiology, Vol. 33, No. 7, 1999.
- Starc TJ, Lipschultz SE, Kaplan S, Easley KA, Bricker JT, Colan SD, Lai WW, Gersony WM, Sopko
G, Moodie DS, Schluchter MD. Cardiac complications in children with human immuno deficiency virus
infection. Pediatrics 104:E14. 1999.
- Westra SJ, Hill JA, Alejos JC, Galindo
A, Boechat MI, Laks H. "Three-Dimensional Helical CT of
Pulmonary Arteries in Infants and Children with Congenital Heart Disease" American Journal of
Roentgenology, 173, July 1999.
Division
Presentations
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Alejos J. "Acute Treatment of the Failing Ventricle" presented at the UCLA Critical Care
Transport Conference at Mattel Children's Hospital on 9/9/99.
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Alejos J. "Evaluation of the Newborn with Cyanosis" presented at the UCLA Critical Care
Transport Conference at Mattel Children's Hospital at UCLA on 9/9/99.
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Alejos J. "Role of the UCLA Cardiac Team in Third World Country" presented at Pediatric Grand
Rounds at Mattel Children's Hospital at UCLA on 6/4/99.
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Alejos J. "Development of UCLA/PAMS Cardiovascular Team and their Work in Lima, Peru" presented
at the AIPEUC (Association of Peruvian Institutions in the US and Canada) XV Convention on 5/28/99.
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Chang R-KR, Klitzner TS. Factors Associated with Age at Operation for Children with Congenital
Heart Disease. J Am Coll Cardiol 1999;33(2), Suppl A:524A Presented at the 48th Annual Scientific Session
of the American College of Cardiology, New Orleans, 3/99.
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Friedman WF. Dennison Young Visiting Professor and keynote lecturer. Society of Pediatric
Cardiology of Greater New York. New York, NY, 4/13/99 4/16/99.
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George B. UCLA Children's Hospital. Pediatric Board Review Course: "Left to Right Shunts and
Congestive Heart Failure". Sunset Village, UCLA campus, Los Angeles, CA. 9/3/99.
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Kudo T, Annala AJ, Dahlbom M, Allada V, Cherry SR, Phelps ME, Schelbert HR. Noninvasive
repeat measurements of regional myocardial blood flow in rats with N-13 ammonia and a small animal high
resolution PET system (abstract), Circulation 100;18:I-89, 1999.
- Lipshultz SE, Easley KA, Orav JE, Kaplan
S, Starc TJ, Bricker JT, Lai WW, Moodie DS, Sopko G,
Colan SD. Cardiac dysfunction and mortality in HIV-infected children: The prospective
(P2C2) HIV-multicenter study.
Circulation; 100, p. I-531 (abstract no. 2795) 1999.
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Odim JN, Laks H, Drinkwater DC Jr, George
Bl, Yun J, Salem M, Allada V. Staged surgical approach
to neonates with aortic obstruction and single-ventricle physiology. (abstract), J Thorac Cardiovasc
Surg, 1999.
- Pampaloni MH, Allada V, Schelbert HR. Perfusion correlation between cardiac positron emission
tomography and angiography in children with suspected coronary abnormalities (abstract), Circulation
100;18:I-88, 1999.
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Silver ME, Chen F, Shannon KM, Geng Y,
Klitzner TS, Krogstad PA. Expression of CXCR4 in human
fetal cardiac myocytes: a role in HIV related cardiomypathy. Pediatr Res; 45(5) Part II:174A, 1999.
Presented at the Society for Pediatric Research Annual meeting, San Francisco, California, 5/99
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