DIVISION OF PULMONOLOGY

Faculty Profiles

BOWMAN, C. MICHAEL

Faculty Member Since:	1996
Degrees:	MD, University of Wisconsin, Madison PhD, University of Wisconsin, Madison, Genetics BS, University of Illinois, Urbana, Chemistry
Rank:	Visiting Associate Professor of Pediatrics
Research Interests:	Mechanisms of injury and repair of the lung in children, early recognition of lung dysfunction and treatment of children with chronic interstitial inflammation and pulmonary fibrosis, improved methods for treatment of lung disease in children with cystic fibrosis.
Grant Support:	1997-present, Genentech, Inc.: "A multi-center, randomized, placebo- controlled, double-blind study to determine the effect of Pulmozyme on pulmonary function decline in subjects with cystic fibrosis aged 6-10 years." Role- Principal Investigator at Collabo rating Center. 1997-present, Nemoirs Childrens Institute: Managed care and healthcare use among CF children. Role-Principal Investigator at Collaborating Center 1997-present, Cystic Fibrosis Foundation: A prospective, longitudinal determination of computed tomography of the chest and systemic markers of inflammation in children with cystic fibrosis aged 6-10 years with mild pulmonary abnormalities. Role _ Principal Investi gator at Collaborating Center. 1998-present, Dupont Merck: "DMP 777-003: A dose escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmaco dynamics of multiple doses of DMP 777 in adult subjects 18 years of age or older with cystic fibrosis." Role _ Principal Investigator at Collaborating Center. 1998-present, Dupont Merck: "DMP 777-004: A multi-dose escalation study to evaluate the lung-specific bioefficacy of oral administration with DMP 777 in adult patients 18 years of age and older with cystic fibrosis. Role _ Principal Investigator at Collaborating Center.
Teaching:	Lecturer; Pediatric Grand Rounds; Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California; January 14, 1999. Lecture: "Cystic Fibrosis 1999: Challenges for the new millennium." Discussant; Liver Transplant Conference; Division of Pediatric Gastroenterology, Childrens Hospital of Los Angeles; February 2, 1999. Discussion: "Factors influencing the progression of lung disease in patients with cystic fibrosis." Lecturer; Pediatric Grand Rounds; White Memorial Hospital, Los Angeles, California; April 22, 1999. Topic: "Cystic Fibrosis, 1999." Lecturer; Postgraduate Evening Seminar; American Thoracic Society Annual Meeting; San Diego, California; April 25, 1999. Lecture: "Other potential applications for aerosol antibiotic therapy." Discussion Leader, Roundtable Discussion; 23rd European Cystic Fibrosis Conference; The Hague, Netherlands; June 10, 1999. Topic: "Use of aerosol antibiotics." Lecturer; Pulmonary Fellows' Orientation Course; Department of Pediatric Pulmonology, Department of Pediatrics, Childrens Hospital of Los Angeles; July 26, 1999. Lecturer; Pediatric Conference; Queen of Angels-Hollywood Presbyterian Hospital, Hollywood, California; September 9, 1999. Topic: "Bronchiolitis 1999 _ Controversies in management." Guest Speaker; Southwestern Pediatric Society; Los Angeles, California; September 29, 1999. Topic: "Cystic fibrosis as we approach the next millennium." Lecturer; Pediatric Conference; Providence St. Joseph's Hospital; Burbank, California; October 12, 1999. Topic: "Bronchiolitis _ Controversies in management."
Professional Committees:	1994-present Member, American Board of Pediatrics

KEENS, THOMAS G.

Faculty Member Since:	1997
Degrees:	MD, University of California, San Diego School of Medicine BA, St. John's College, Santa Fe, New Mexico
Rank:	Visiting Professor
Research Interests:	Sudden infant death syndrome, congenital central hypoventilation syndrome, home mechanical ventilation; development of respiratory control, ventilatory muscle fatigue; developmental respiratory physiology.
Grant Support:	1991-99. T. Hoppenbrouwers and T.G. Keens. Home Apnea Monitoring in Infants at Increased Risk for SIDS; National Institute of Child Health and Human Development. 1998-99. Effect of Development and Sleeping Position on Hypoxic and Hypercapnic Arousal Responses; Sudden Infant Death Syndrome Alliance.
Professional Committees:	Southern California Regional SIDS Council California Sudden Infant Death Syndrome Program State of California Department of Health Services California Sudden Infant Death Syndrome Advisory Council for the Department of Health Services, State of California Department of Health Services Board of Directors, Sudden Infant Death Syndrome Foundation of Southern California, Pasadena, California Consensus Development Committee on the Diagnosis and Management of Congenital Central Hypoventilation Syndrome, American Thoracic Society, New York, New York. Co-Chair, Committee on Indications for Home Cardiorespiratory Monitoring in Infants, American Thoracic Society, New York, New York. Asthma Advisory Committee, Southern California Blue Cross, Los Angeles, California.
Honors:	1999, Ray Kroc Visiting Professor of Pediatrics, Milton S. Hershey Medical Center Children's Hospital, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

LEW, CHERYL D.

Faculty Member Since:	1996
Degrees:	MD, University of California, San Diego, 1972 BA, University of California, Los Angeles, 1968
Rank:	Visiting Associate Professor of Pediatrics
Research Interests:	Prenatal assessment of fetal maturity; lung development in the fetus and newborn; ventilatory control mechanisms in the newborn, influence of environmental and hormonal factors on surfactant synthesis and secretion; pharmacologic therapy of intractable asthma; patent ductus arteriosus in the premature infant: traditional methods vs. pharmacologic or surgical therapy; pulmonary development of the brain-damaged fetus; cardiopulmonary consequences of severe perinatal asphyxia; neonatal lung mechanics; integrative neurological control of cardiopulmonary function in the term and premature newborn; influence of vasoactive drugs on pulmonary circulation; effect of the newborn intensive care experience on infant development and behavior, and competency of the caretaker; evolution of lung injury and development of infantile chronic lung disease; modifying influences on the course of infantile chronic lung disease; innovative techniques of management of neonatal respiratory failure; factors influencing parental decision-making about end of life issues.
Teaching:	Pediatric Grand Rounds "Ethical Issue-Treating Pediatric Respiratory Failure"; Pediatric Resident and Nurse Practitioner Elective Rotation
Professional Committees:	1983-present, Childrens Hospital of Los Angeles, Hospital Infection Control Committee 1993-present, Childrens Hospital of Los Angeles, Ethics Resource Committe 1990-present Childrens Hospital of Los Angeles, Antibiotics Subcommittee of the Pharmacy & Therapeutics Committee 1998-present Childrens Hospital of Los Angeles, Chaplaincy Advisory Board

PLATZKER, ARNOLD C.G.

Faculty Member Since:	1996
Degrees:	MD, Tufts University School of Medicine AB, Brown University, Providence, Rhode Island
Rank:	Visiting Professor, Chief, Division of Pediatric Pulmonology
Rank:	Lung development in the fetus and newborn, treatment of intractable respiratory failure in Pediatrics, new methods for assessment of lung function in infants and children, lung complications of Human Immunodeficiency Disease (HIV), childhood antecedents of adult lung disease
Grant Support:	1989-99 Long-term Pulmonary and Cardiac Outcome of HIV Infection in Infants at Birth
Teaching:	Pediatric Grand Rounds Pediatric Housestaff Noon Conferences Pediatric Resident and Nurse Practitioner Elective Rotation
Professional Committees:	Research Grant Review Committee, American Lung Association of Los Angeles County Committee on Publications _ American Journal of Respiratory and Critical Care Medicine, American Journal of Respiratory Cell & Molecular Biology Member, Executive Committee of P2C2 Study, NHLBI Chair, Pulmonary Subcommittee of P2C2 Study, NHLBI Co-Investigator _ Study of Pediatric Pulmonary and Cardiac, NHLBI Complications of HIV Infection (P2C2 Study), NHLBI
Honors:	Life Member, Clare Hall, Cambridge University, UK Who's Who in California, in the West, in American Education, in Healthcare and Medicine Men of Achievement (International Biographical Center, Cambridge, UK Best Doctors of America

SAEED, M. MUNAWAR

Faculty Member Since:	1999
Degrees:	DJ, Science College, Karachi, Pakistan  MB, BS, University of Karachi, Dow Medical College, Karachi, Pakistan;
Research Interests:	Magnetic imaging of the brain during ventilatory, challenges in patients with congenital central hypoventilation syndrome, effect of development and sleeping position on hypoxic and hypercapnic arousal responses, infant PFTs in patients with kyphoscoliosis, before and after repair; ventilatory pattern abnormalities in infants of cocaine abusing mothers (ICAM) during sleep.
Teaching:	University of Southern California School of Pharmacy; February, 1999. Lecture: Respiratory Physiology.

Division Publications

1. Mittler MA, Keens TG and McComb JG. Image of the month: Joubert's syndrome. Pediatric Neurosurgery, 30: 218, 1999.
2. Nield, TA, Langenbacher D, Poulsen MK, Platzker ACG. Neurodevelopmental outcome at 3.5 years of age in children treated with extracorporeal life support (ECMO): relationship to primary diagnosis (in press _ Journal of Pediatrics).
3. Platzker ACG, Colin AA, Chen XC, Hiatt P, Hunter J, Koumbourlis AC, Schluchter MD, Ting A, Wohl ME. The P2C2 HIV Study. Thoracoabdominal compression and respiratory system compliance in infants of HIV-infected mothers (in press, AJRCCM.)
4. Ramsey BW, Pepe MS, Quan JM, Otto KL, Montgomery AB, Williams-Warren J, Vasilijev-K M, Borowitz D, Bowman CM, et. al. Efficacy and safety of chronic intermittent administration of inhaled tobramycin in patients with cystic fibrosis. 1999.
5. Saeed MM, Woo MS, MacLaughlin EF, Margetis MF and Keens TG. Prognosis in pediatric idiopathic pulmonary hemosiderosis. Chest, 116:721-725, 1999.
6. Wang JJ, Bowman CM, Hsu E, Wertz K, Wong LC. A novel mutation in the CFTR gene correlates with severe clinical phenotype in seven Hispanic patients. J Med Gen, in press, 1999.
7. Weese-Mayer DE, Shannon DC, Keens TG and Silvestri JM. Idiopathic congenital central hypoventilation syndrome: Diagnosis and management. American Journal of Respiratory and Critical Care Medicine, 160: 368-373, 1999.